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SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc picolinate)
22 mg
200%
Top Medical Research Studies
8
Zinc compounds enhance breast cancer treatment
Albumin-based nanocarriers loaded with novel Zn(II)-thiosemicarbazone compounds chart a new path for precision breast cancer therapy.
High relevance for breast cancer
Our exploration delves into the effects of zinc-based compounds, specifically Zn(II)-thiosemicarbazones, on breast cancer treatment. By utilizing bovine serum albumin as a nanocarrier, we aimed to enhance the stability and effectiveness of these compounds against breast cancer cells.
We observed that when these zinc compounds were loaded onto albumin, they performed significantly better in killing cancer cells compared to their standalone forms. The small size of the nanocarriers—32 nm for Alb-ZnTcA and 43 nm for Alb-ZnTcB—appeared to facilitate cellular uptake, which likely contributed to their increased potency. In particular, Alb-ZnTcA stood out with the highest levels of cytotoxicity.
Furthermore, our examinations suggested that both types of albumin-bound compounds primarily induce cell death through apoptosis—a natural process of cellular self-destruction. This mechanism is advantageous, as it prevents the uncontrolled proliferation of cancer cells that characterizes breast cancer.
Overall, our findings suggest that zinc compounds packaged within albumin nanocarriers could pave a promising path for effective, targeted breast cancer therapies. The ability of these compounds to work at lower concentrations indicates a potential to reduce side effects, offering a thoughtful approach to treatment.
We observed that when these zinc compounds were loaded onto albumin, they performed significantly better in killing cancer cells compared to their standalone forms. The small size of the nanocarriers—32 nm for Alb-ZnTcA and 43 nm for Alb-ZnTcB—appeared to facilitate cellular uptake, which likely contributed to their increased potency. In particular, Alb-ZnTcA stood out with the highest levels of cytotoxicity.
Furthermore, our examinations suggested that both types of albumin-bound compounds primarily induce cell death through apoptosis—a natural process of cellular self-destruction. This mechanism is advantageous, as it prevents the uncontrolled proliferation of cancer cells that characterizes breast cancer.
Overall, our findings suggest that zinc compounds packaged within albumin nanocarriers could pave a promising path for effective, targeted breast cancer therapies. The ability of these compounds to work at lower concentrations indicates a potential to reduce side effects, offering a thoughtful approach to treatment.
Read More
9
Zinc nanoparticles show anticancer potential
The effect of biosynthesized zinc oxide nanoparticles on gene expression and apoptosis in triple-negative breast cancer cells.
Highly relevant for cancer treatment
We explored the potential of zinc oxide nanoparticles (ZnO NPs) synthesized from Berberis integerrima fruit extract to combat triple-negative breast cancer (TNBC). Our study aimed to evaluate their biocompatibility and anticancer effects by investigating their impact on human cancer cell lines.
We conducted various analyses including MTT assays and flow cytometry to assess how these nanoparticles affected both normal and cancerous cells. The results were promising; we found that ZnO NPs demonstrated a significant anticancer effect, particularly against MDA-MB-231 and MDA-MB-468 cell lines, while remaining safe for healthy human fibroblast cells.
The IC50 values highlighted that even at relatively low concentrations, these nanoparticles showed the ability to inhibit cancer cell growth effectively. Our research indicates that biosynthesized ZnO NPs could be a viable option in the search for alternative therapies for challenging cancer types like TNBC, offering a potentially eco-friendly and cost-effective strategy to tackle this critical health issue.
We conducted various analyses including MTT assays and flow cytometry to assess how these nanoparticles affected both normal and cancerous cells. The results were promising; we found that ZnO NPs demonstrated a significant anticancer effect, particularly against MDA-MB-231 and MDA-MB-468 cell lines, while remaining safe for healthy human fibroblast cells.
The IC50 values highlighted that even at relatively low concentrations, these nanoparticles showed the ability to inhibit cancer cell growth effectively. Our research indicates that biosynthesized ZnO NPs could be a viable option in the search for alternative therapies for challenging cancer types like TNBC, offering a potentially eco-friendly and cost-effective strategy to tackle this critical health issue.
Read More
8
Zinc intake influences breast cancer
Associations between dietary intake of zinc and selenium and breast cancer: findings from a NHANES cross-sectional study.
Moderate significance but limiting factors
We set out to understand how dietary zinc might influence breast cancer risk among women. Using data from a large survey that included over 25,000 participants, we looked at various factors such as zinc intake levels and whether these were associated with the prevalence of breast cancer.
Our findings revealed that women diagnosed with breast cancer tended to have lower dietary zinc intake compared to those without the disease. Specifically, women with breast cancer reported an average zinc intake of 10.2 mg, while the control group averaged 12.0 mg. Additionally, our analysis showed a significant protective association; higher levels of zinc were linked to a reduced likelihood of having breast cancer.
We also uncovered some interesting insights regarding certain biomarkers related to metabolism, like bilirubin and uric acid, which appeared to play a role in this relationship. For instance, bilirubin seems to mediate some of the protective effects of zinc against breast cancer.
Overall, while we observed negative correlations between dietary zinc and breast cancer, it's important to note that this study cannot conclusively state that increasing zinc intake will directly lead to lower breast cancer rates due to potential confounding factors. Thus, more focused research is needed to fully understand the therapeutic potential of zinc in this context.
Our findings revealed that women diagnosed with breast cancer tended to have lower dietary zinc intake compared to those without the disease. Specifically, women with breast cancer reported an average zinc intake of 10.2 mg, while the control group averaged 12.0 mg. Additionally, our analysis showed a significant protective association; higher levels of zinc were linked to a reduced likelihood of having breast cancer.
We also uncovered some interesting insights regarding certain biomarkers related to metabolism, like bilirubin and uric acid, which appeared to play a role in this relationship. For instance, bilirubin seems to mediate some of the protective effects of zinc against breast cancer.
Overall, while we observed negative correlations between dietary zinc and breast cancer, it's important to note that this study cannot conclusively state that increasing zinc intake will directly lead to lower breast cancer rates due to potential confounding factors. Thus, more focused research is needed to fully understand the therapeutic potential of zinc in this context.
Read More
Most Useful Reviews
8.8
Reduces breast pain
Super 💪 I never tire of praising Solgar products! This zinc is fantastic: easily absorbed, one tablet a day, sufficient for a full three-month course. My skin isn’t oily, and my nails and hair are strong. Most importantly, I noticed my breasts no longer feel full or painful before menstruation. Perhaps this is due to taking selenium and vitamin E alongside the zinc, also from Solgar. I felt the benefits within the first month. I even give zinc to my husband, who isn't keen on pills but values the combo for its health benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8.1
9
Impact of Zinc on Breast Cancer
Interaction of zinc oxide nanoparticles and nanorods with immunoglobulin G and underlying effects on MCF-7 breast cancer cells.
Challenging to isolate zinc effects
We investigated how zinc oxide nanoparticles (ZnO NPs) and nanorods (ZnO NRs) interact with a protein called immunoglobulin G (IgG) and the subsequent effects on breast cancer cells, specifically the MCF-7 line. By looking closely at these interactions, we aimed to understand zinc's potential role in breast cancer treatment.
Our findings showed that when ZnO NPs interacted with IgG, they experienced changes that suggested increased stability but also a notable decrease in zeta potential, meaning their charge became less favorable. In contrast, ZnO NRs had a different interaction pattern with IgG, pointing to a more significant alteration in the structure of IgG itself. We also discovered that both ZnO NPs and NRs had varying levels of cytotoxicity against MCF-7 cells, with the combination of ZnO NRs and IgG leading to the highest level of cell death.
While these results indicate that zinc oxide in various forms can impact breast cancer cells, it's essential to note that the presence of IgG complicated the interpretation of zinc's direct effects. Overall, we did observe a potential pathway for zinc's effectiveness against breast cancer through these nanoparticles and their protein interactions.
Our findings showed that when ZnO NPs interacted with IgG, they experienced changes that suggested increased stability but also a notable decrease in zeta potential, meaning their charge became less favorable. In contrast, ZnO NRs had a different interaction pattern with IgG, pointing to a more significant alteration in the structure of IgG itself. We also discovered that both ZnO NPs and NRs had varying levels of cytotoxicity against MCF-7 cells, with the combination of ZnO NRs and IgG leading to the highest level of cell death.
While these results indicate that zinc oxide in various forms can impact breast cancer cells, it's essential to note that the presence of IgG complicated the interpretation of zinc's direct effects. Overall, we did observe a potential pathway for zinc's effectiveness against breast cancer through these nanoparticles and their protein interactions.
Read More
9
Zinc nanoparticles show anticancer potential
The effect of biosynthesized zinc oxide nanoparticles on gene expression and apoptosis in triple-negative breast cancer cells.
Highly relevant for cancer treatment
We explored the potential of zinc oxide nanoparticles (ZnO NPs) synthesized from Berberis integerrima fruit extract to combat triple-negative breast cancer (TNBC). Our study aimed to evaluate their biocompatibility and anticancer effects by investigating their impact on human cancer cell lines.
We conducted various analyses including MTT assays and flow cytometry to assess how these nanoparticles affected both normal and cancerous cells. The results were promising; we found that ZnO NPs demonstrated a significant anticancer effect, particularly against MDA-MB-231 and MDA-MB-468 cell lines, while remaining safe for healthy human fibroblast cells.
The IC50 values highlighted that even at relatively low concentrations, these nanoparticles showed the ability to inhibit cancer cell growth effectively. Our research indicates that biosynthesized ZnO NPs could be a viable option in the search for alternative therapies for challenging cancer types like TNBC, offering a potentially eco-friendly and cost-effective strategy to tackle this critical health issue.
We conducted various analyses including MTT assays and flow cytometry to assess how these nanoparticles affected both normal and cancerous cells. The results were promising; we found that ZnO NPs demonstrated a significant anticancer effect, particularly against MDA-MB-231 and MDA-MB-468 cell lines, while remaining safe for healthy human fibroblast cells.
The IC50 values highlighted that even at relatively low concentrations, these nanoparticles showed the ability to inhibit cancer cell growth effectively. Our research indicates that biosynthesized ZnO NPs could be a viable option in the search for alternative therapies for challenging cancer types like TNBC, offering a potentially eco-friendly and cost-effective strategy to tackle this critical health issue.
Read More
8
Zinc intake influences breast cancer
Associations between dietary intake of zinc and selenium and breast cancer: findings from a NHANES cross-sectional study.
Moderate significance but limiting factors
We set out to understand how dietary zinc might influence breast cancer risk among women. Using data from a large survey that included over 25,000 participants, we looked at various factors such as zinc intake levels and whether these were associated with the prevalence of breast cancer.
Our findings revealed that women diagnosed with breast cancer tended to have lower dietary zinc intake compared to those without the disease. Specifically, women with breast cancer reported an average zinc intake of 10.2 mg, while the control group averaged 12.0 mg. Additionally, our analysis showed a significant protective association; higher levels of zinc were linked to a reduced likelihood of having breast cancer.
We also uncovered some interesting insights regarding certain biomarkers related to metabolism, like bilirubin and uric acid, which appeared to play a role in this relationship. For instance, bilirubin seems to mediate some of the protective effects of zinc against breast cancer.
Overall, while we observed negative correlations between dietary zinc and breast cancer, it's important to note that this study cannot conclusively state that increasing zinc intake will directly lead to lower breast cancer rates due to potential confounding factors. Thus, more focused research is needed to fully understand the therapeutic potential of zinc in this context.
Our findings revealed that women diagnosed with breast cancer tended to have lower dietary zinc intake compared to those without the disease. Specifically, women with breast cancer reported an average zinc intake of 10.2 mg, while the control group averaged 12.0 mg. Additionally, our analysis showed a significant protective association; higher levels of zinc were linked to a reduced likelihood of having breast cancer.
We also uncovered some interesting insights regarding certain biomarkers related to metabolism, like bilirubin and uric acid, which appeared to play a role in this relationship. For instance, bilirubin seems to mediate some of the protective effects of zinc against breast cancer.
Overall, while we observed negative correlations between dietary zinc and breast cancer, it's important to note that this study cannot conclusively state that increasing zinc intake will directly lead to lower breast cancer rates due to potential confounding factors. Thus, more focused research is needed to fully understand the therapeutic potential of zinc in this context.
Read More
8
Zinc and Pimozide synergy
Synergistic Therapeutic Effects of Zn ions and Pimozide in Breast Cancer Cells.
Effective dual action observed
We observed that zinc (Zn) ions can be a crucial player in treating breast cancer, especially when combined with repurposed drugs like Pimozide. The study examined how these zinc ions, delivered through a special pH-responsive structure, enhance the effectiveness of cancer treatment.
By creating a zinc-based compound, researchers were able to encapsulate Pimozide efficiently, leading to significant drug release in a simulated tumor environment. This suggests that the treatment could be especially potent in the acidic conditions often found in tumors.
The in-vitro tests revealed that combining Pimozide with zinc not only improved the drug's effectiveness but also triggered two forms of programmed cell death—ferroptosis and apoptosis—in breast cancer cells. The findings point to a promising dual-action therapeutic strategy that targets cancer more effectively.
By creating a zinc-based compound, researchers were able to encapsulate Pimozide efficiently, leading to significant drug release in a simulated tumor environment. This suggests that the treatment could be especially potent in the acidic conditions often found in tumors.
The in-vitro tests revealed that combining Pimozide with zinc not only improved the drug's effectiveness but also triggered two forms of programmed cell death—ferroptosis and apoptosis—in breast cancer cells. The findings point to a promising dual-action therapeutic strategy that targets cancer more effectively.
Read More
8
Zinc's Impact on Breast Cancer
Implanted Microneedles Loaded with Sparfloxacin and Zinc-Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple-Negative Breast Cancer to Prevent Recurrence and Metastasis.
Study reflects multifaceted zinc use
We explored the potential of zinc, specifically in the form of zinc-manganese sulfide nanoparticles, as a treatment to prevent postoperative recurrence of triple-negative breast cancer (TNBC). The study focused on evaluating how these nanoparticles, combined with Sparfloxacin, can bolster the immune response against cancer cells while also safeguarding against infections.
Our findings highlighted that the zinc-manganese nanoparticles not only possess strong antibacterial properties, but they also induce a response in the immune system. They do this by generating reactive oxygen species that promote immunogenic cell death, which helps in activating various immune cells to target tumor growth.
Overall, we observed significant benefits in terms of reduced tumor growth and lung metastasis. Importantly, the nanoparticles led to increased immune cell activation, showing promise for enhancing both local and systemic immune responses in TNBC patients. This research opens up new avenues for utilizing zinc as a crucial part of cancer treatment strategies.
Our findings highlighted that the zinc-manganese nanoparticles not only possess strong antibacterial properties, but they also induce a response in the immune system. They do this by generating reactive oxygen species that promote immunogenic cell death, which helps in activating various immune cells to target tumor growth.
Overall, we observed significant benefits in terms of reduced tumor growth and lung metastasis. Importantly, the nanoparticles led to increased immune cell activation, showing promise for enhancing both local and systemic immune responses in TNBC patients. This research opens up new avenues for utilizing zinc as a crucial part of cancer treatment strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Reduces breast pain
Super 💪 I never tire of praising Solgar products! This zinc is fantastic: easily absorbed, one tablet a day, sufficient for a full three-month course. My skin isn’t oily, and my nails and hair are strong. Most importantly, I noticed my breasts no longer feel full or painful before menstruation. Perhaps this is due to taking selenium and vitamin E alongside the zinc, also from Solgar. I felt the benefits within the first month. I even give zinc to my husband, who isn't keen on pills but values the combo for its health benefits.
Read More
